Arava/Leflunomide IS USED FOR:

Reducing signs and symptoms of rheumatoid arthritis. It is also used to improve physical function and to prevent the development of structural damage to the joints.

Leflunomide/Arava is a pyrimidine synthesis inhibitor. It is thought to work by blocking certain enzymes responsible for abnormal tissue development or growth.

BEFORE USING Arava/Leflunomide :

Some medical conditions may interact with Leflunomide/Arava . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you have hepatitis B or C or other liver problems, kidney problems, or drink alcoholic beverages
• if you are breast-feeding
• if you have allergies to medicines, foods, or other substances
• if you have a weakened immune system, blood or bone marrow disorders, an infection, or have recently received a vaccination
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

Some MEDICINES MAY INTERACT with Leflunomide/Arava . Tell your health care provider if you are taking any other medicines, especially any of the following:

• Methotrexate/Rheumatrex or rifampin because side effects, including liver toxicity, headache, and muscle pains, may occur
• Cholestyramine because the effectiveness of Leflunomide/Arava may be decreased
• Anticoagulants (eg, warfarin/Coumadin) because side effects, including risk of bleeding, may be increased by Leflunomide/Arava

This may not be a complete list of all interactions that may occur. Ask your health care provider if Leflunomide/Arava may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

HOW TO USE Arava/Leflunomide :

Use Leflunomide/Arava as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• It may take 4 weeks or more to notice any improvement while taking Leflunomide/Arava .
• If you miss a dose of Leflunomide/Arava , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
• Leflunomide/Arava may be taken with or without food.

Ask your health care provider any questions you may have about how to use Leflunomide/Arava .

DO NOT USE Arava/Leflunomide IF:

• you are pregnant or planning to become pregnant
• you are allergic to any ingredient in Leflunomide/Arava

Contact your doctor or health care provider right away if any of these apply to you.

POSSIBLE SIDE EFFECTS OF Arava/Leflunomide :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Back pain; bronchitis; diarrhea; dizziness; dry skin; hair loss; headache; increased cough; indigestion; joint disorder; loss of appetite; muscle aches; nausea; runny nose; sinus infection; upper respiratory tract infection; urinary tract infection; vomiting; weakness; weight loss.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blistering or peeling skin; blisters on the inside of eyes, nose, or mouth; chest pain; dark urine; easy bruising/bleeding; feelings of numbness or tingling; fever; infection; muscle cramps, including leg cramps; pale skin; pale stools; sore throat; stomach pain; unusual tiredness; vomiting; yellowing of the eyes or skin.

Arcoxia Etoricoxib

IMPORTANT SAFETY INFORMATION:

• LAB TESTS, including liver function, may be performed to monitor your progress or check for side effects. Be sure to keep all doctor and lab appointments.
• Contact your doctor immediately if you develop a skin rash, small blisters over a large portion of the body, or lesions around the eyes, mouth, or throat.
• Leflunomide/Arava is not recommended for use in CHILDREN younger than 18 years of age. Safety and effectiveness in this age group have not been confirmed.
• Drinking alcohol while you are taking Leflunomide/Arava may increase the risk of liver problems. Talk with your doctor before drinking alcohol while taking Leflunomide/Arava .
• Leflunomide/Arava may cause birth defects in children of men taking Leflunomide/Arava at the time of conception. Discuss the use of reliable birth control methods (eg, condoms) with your doctor or pharmacist while taking Leflunomide/Arava . Talk with your health care provider about stopping Leflunomide/Arava if you and your female partner are planning for parenthood.
• Avoid receiving vaccines while taking Leflunomide/Arava .
• PREGNANCY and BREAST-FEEDING: Leflunomide/Arava may cause harm to the fetus. Leflunomide/Arava must not be used during pregnancy, or by women who are able to become pregnant unless they are using reliable forms of birth control. A negative pregnancy test must be obtained before the start of treatment with Leflunomide/Arava . Contact your health care provider at once if your menstrual flow is delayed or if you suspect that you are pregnant. After completing therapy, women of childbearing potential who plan to become pregnant must undergo a procedure to flush any remaining medicine out of the body system. It is unknown if Leflunomide/Arava is excreted in breast milk. Do not breast-feed while taking Leflunomide/Arava .

What is the shelf life of the pills?

• The expiry date is mentioned on each blister. It is different for different batches. The shelf life is 2 years from the date of manufacture and would differ from batch to batch depending on when they were manufactured.